Efficacy versus effectiveness in clinical trials
نویسندگان
چکیده
منابع مشابه
Comparative efficacy versus effectiveness of initial antiretroviral therapy in clinical trials versus routine care.
BACKGROUND The applicability of clinical trial findings (efficacy) to the routine care setting (effectiveness) may be limited because of study eligibility criteria and volunteer bias. Although well-chronicled in many conditions, the efficacy versus effectiveness of antiretroviral therapy (ART) remains understudied. METHODS A retrospective study of the University of Alabama at Birmingham 1917 ...
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We propose an "efficacy-to-effectiveness" (E2E) clinical trial design, in which an effectiveness trial would commence seamlessly upon completion of the efficacy trial. Efficacy trials use inclusion/exclusion criteria to produce relatively homogeneous samples of participants with the target condition, conducted in settings that foster adherence to rigorous clinical protocols. Effectiveness trial...
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This article discusses common pitfalls of multisite randomized clinical trials of efficacy and effectiveness. Issues considered include (1) premature initiation, (2) ineffective study structure, (3) too much or too little communication among researchers, (4) neglect of site differences, (5) use of "naked" p values, (6) premature closure, and (7) overreliance on the interpretation and memory of ...
متن کاملEfficacy versus Effectiveness
reflect routine practice; 2) the intervention should be provided by normal staff with routine training; 3) the control may therefore be routine practice rather than a placebo; 4) outcome measures are usually patient centered and incorporate broad measures of health-related quality of life. The editorial board, reviewer, and authors must all have such an understanding to achieve the aims and sco...
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Background: Acute myocardial infarction (AMI) is the leading cause of death throughout the world. One of the standard approaches to treatment of AMI is fibrinolysis. The study was conducted to evaluate the clinical efficacy of tenecteplase versus reteplase through network meta-analysis for AMI. Methods: Randomized trials were comprehensively searched in PubMed, Scopus, Cochrane library, a...
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ژورنال
عنوان ژورنال: The Bone & Joint Journal
سال: 2017
ISSN: 2049-4394,2049-4408
DOI: 10.1302/0301-620x.99b4.bjj-2016-1247